The setting you are referring to is for Overlapping Open. This is a CIFS feature. This setting is to enable Overlapping Open for only certain file extensions, or to enable for all except certain extensions. If you enable the Overlapping Opens feature you then select one of the two above mentioned settings. If Overlapping Opens is enable, the default is to provide this optimization feature for file extensions "doc, pdf, ppt, sldasm, slddrw, slddwg, sldprt, txt, vsd, xls". You can select the second option which is to use this optimization feature for all files except for those with extensions "ldb, mdb". The file extensions are just the defaults and you can change them. Overlapping Open is a specific CIFS feature so the setting applies to this feature only and not to CIFS optimization in general. With Overlapping Open turned off the Steelhead will still perform latency and bandwidth optimization if it can. As I understand the Overlapping Open feature its intent is to move CIFS lock management from the client to the Steelhead. This allows Oplocks to be held in situations where applications open the same file multiple times (a curious behavior) so latency optimization can occur.